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Titin Antibody
Ordering Recommendation
Secondary diagnostic testing for myasthenia gravis when first-line diagnostic tests are negative. Screen for presence of thymoma in patients with myasthenia gravis.
New York DOH Approval Status
Specimen Required
Plain Red or Serum Separator Tube (SST).
Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min. 0.5 mL)
Refrigerated. Also acceptable: Frozen
Moderately icteric specimens.
After separation from cells: Ambient: 72 hours; Refrigerated: 1 week; Frozen: 1 month (avoid multiple freeze/thaw cycles)
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Thu
Reported
1-8 days
Reference Interval
| Test Number |
Components |
Reference Interval |
|---|---|---|
| Titin Antibody | 0.45 IV or less |
Interpretive Data
The presence of titin antibody is associated with late onset of myasthenia gravis (MG) and a variable risk for thymoma. Titin antibody may be detected in 20-40 percent of all patients with MG; higher frequency in older population as a whole.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
| Component | Interpretation |
|---|---|
| Titin Antibody | 0.00-0.45 IV: Negative 0.46-0.71 IV: Indeterminate 0.72 IV or greater: Positive |
Laboratory Developed Test (LDT)
Note
Hotline History
CPT Codes
83516
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 2005637 | Titin Antibody | 100371-4 |
Aliases
- Tintin Ab
